Proceedings: Recent results with carcinogen binding proteins
نویسندگان
چکیده
منابع مشابه
BINDING OF NAPROXEN TO SERUM PROTEINS IN PATIENTS WITH LIVER CIRRHOSIS AND HEALTHY INDIVIDUALS
A three-fold decrease of the in vitro ability of serum proteins to bind naproxen was shown in patients with cirrhosis of the liver compared to healthy individuals. This decrease was caused by quantitative changes in serum proteins in the sera of patients with liver damage. Lower doses of naproxen are therefore suggested in the treatment of patients with liver dysfunction.
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Studies were carried out on the in vitro covalent binding of the carcinogen trichloroethylene (TCE) to liver microsomal preparations and to exogenous DNA. The binding of TCE to liver microsomal proteins of male C57BL/6 X C3H/He F1 (hereafter called B6C3F1) hybrid mice, a species and strain susceptible to TCE-induced liver tumorigenesis, was 46% higher than that of [14C]TCE to microsomal protein...
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Benzo[alpha]pyrene diol epoxide (BPDE) is a well-studied environmental carcinogen that binds covalently to DNA. Here we describe a photochemical technique that allows us to map BPDE-binding sites within cloned gene sequences. The technique is based upon our observation that, when irradiated with laser light at 355 nm, one single-strand DNA cut is produced at each BPDE binding site. In initial e...
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Nearly thirty years ago, the E288 experiment at Fermilab reported [1] the observation of a significant excess in the number of events near 9.5 GeV in the spectrum of the invariant mass of μμ produced in a proton beam on a nuclear target. Over the course of the subsequent two decades the spectrum of this newly-discovered heavy quarkonium system was fleshed out in some detail. Experiments which c...
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A summary of recent results from ZEUS is presented. New ZEUS results from HERA-1 data include Structure Functions, QCD fits, analysis of hadronic final states, precision measurements of αs, production of heavy flavor mesons and baryons and studies of diffraction. Results from the new HERA-II running include the measurement of the cross section for polarized charged current events and charm even...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1974
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1974.155